| 名稱 | TP53 p.R248W Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10141 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | TP53 p.R248W Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10141TP53 p.R248W Reference Standard 標(biāo)準(zhǔn)品
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CBP10141 | |
| Format | Genomic DNA |
| Description | TP53 R248W is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R248W results in decreased transactivation of Tp53 target genes, increased cell proliferation in culture, and increased tumorigenesis in mice, and leads to decreased ATM activation, resulting in increased genetic instability (PMID: 17417627, PMID: 14743206). |
| Technical Data | |
| DNA Change: | c.742C>T |
| AA Change | p.R248W |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10656 |
| Chr position(GRCh37) | chr17:7577539 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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